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Over the past 35 years, the term “leaky vaccine” has gained widespread use in both mathematical modeling and epidemiologic methods for evaluating vaccines Leaky vaccines work by enhancing host immunity to a particular pathogen, without necessarily blocking or slowing viral replication Here, we present a short history, as we recall it, of how the term was coined in the context of the history of sporozoite malaria vaccines that were thought in the 1980s to be possibly.

Claims the measles vaccine effectiveness wanes at a rate of nearly 5% a year, an assertion medical experts dispute. Leaky vaccines are common for animal infections, including marek's disease. Leaky vaccines therefore protect subjects with fewer exposures at a higher effective rate than subjects with more.

They allow the spread of deadlier pathogens that would normally burn out quickly

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