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With a paucity of literature comparing the 2 agents, there is clinical. The effect of andexanet alfa, an agent that reverses the effects of factor xa. Kcentra and andexxa are both reasonable options for factor xa reversal in major bleeding

While andexxa appears to have good hemostatic efficacy, it has greater risk of thrombotic events, specifically cerebrovascular events, compared to kcentra, and no differences in mortality. Patients with acute intracerebral hemorrhage who are receiving factor xa inhibitors have a risk of hematoma expansion This document provides recommendations for reversing anticoagulants in patients with bleeding complications

It compares different reversal agents, including pcc (kcentra®), and their mechanisms, onset, duration, and notes.

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